Sentence examples for directs repression from inspiring English sources

Furthermore, DNMT3L is able to recruit histone deacetylases through its PHD zinc-finger-like motif and possibly directs repression onto newly established imprints (Aapola et al. 2002; Deplus et al. 2002).

Here, we provide evidence of a second mechanism of WG/WNT directed repression, namely Direct Repression [44].

As it functions as a key negative-feedback regulator of conidiation, vosA is necessary and sufficient to direct repression of brlA and development.

miR-203 regulates the epidermal keratinocyte differentiation and directed repression of p63 expression [ 12, 13].

Alternative transcript splicing and polyadenylation can eliminate miRNA regulatory sites from a message, and miRNA directed repression can be blocked by certain RNA binding proteins.

Functionally, JMJD2A could interact with histone deacetylase (HDAC) and retinoblastoma protein (pRb) and could direct repression of E2F-responsive promoters [ 21].

Despite the lack of Hdac1 binding to her6 promoter sequences, this gene remains a candidate direct target for direct repression by Hdac1, as Hdac1 repressed her6 expression in restricted regions of the CNS from 12 hpf onwards.

Tbx16 locks cells into the mesodermal state by not only activating downstream mesodermal genes, but also by repressing bipotential progenitor genes, in part through a direct repression of sox2.

There are, obviously, other means of more direct repression.

Surjit, M. et al. Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor.

A direct repression could be achieved by direct constitutive association of CNOT2 with chromatin at the MHC II locus.