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We have demonstrated that GlnR is the global nitrogen response regulator in M. smegmatis, directly regulating the expression of more than 100 genes.
However, although CMs bind promiscuously to TEs in a complex chromatin environment, it is unclear if they are directly regulating the expression and chromatin state of these TEs.
The results implied that LSD1 might promote these proinflammatory mediator expression by regulating other inflammatory genes or pathways rather than directly regulating their expression.
We found that mutation of Ask10p did not increase xylose isomerase activity through interacting with the xylose isomerase protein or through directly regulating the xylA gene transcription.
By directly regulating the expression of enzymes of free fatty acid metabolism and of UCP-2, leptin controls intracellular triglyceride content of certain nonadipocytes, as well as adipocytes.
GCs may induce apoptosis by directly regulating typical apoptosis or survival genes or by inducing cellular distress that triggers the apoptotic cascade [38].
In the absence of laws directly regulating these events, the San Francisco authorities seek to clamp-down on them by catching venue owners on other charges, such as permitting unlicensed alcohol sales on the premises.
However, there are no reports of TWEAK directly regulating any of these MyHCf isoforms.
There is limited information on the role that G proteins play in directly regulating the sensitivity of a cell's response to an external stimulus in living cells.
For example, JAG1 constitutes an instructive signal for Th2 differentiation by inducing GATA3 and by directly regulating IL4 gene transcription [39].
These results suggest that p38 is directly regulating the expression of a subset of AVE genes.
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