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This isn't what Shiller has been directly recognised for today, of course.
To date, there is no available structural information on domains from rice NLRs, and no structural data from any system showing how plant pathogen effectors are directly recognised at the molecular level by an NLR.
H3K27me3 can be directly recognised by one of five chromodomain-containing proteins (CBX2, 4, 6, 7 and 8), which subsequently recruit PRC1 to chromatin by simultaneously interacting with the E3 ubiquitin ligase Ring1B through a C-terminal domain (Kaustov et al, 2011).
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Nod1 LRR also distributed with the bacterial pellet demonstrating that it too can directly recognise bacteria.
The second and simpler approach uses immobilised antibodies to directly recognise specific tag-labelled amplicons [ 11, 12, 16, 17].
They could directly recognise pre-existing CenH3-nucleosomes, specific histone modifications or, alternatively, be recruited through factors that would act as receptor complexes for incoming CenH3.
As shown in Figure 6B, the S11 clone was effective in directly recognising MCF-7 and this recognition was completely inhibited by anti-HLA-DR mAbs.
In addition, the CD4 T cells were capable of directly recognising and killing HNSCC cells expressing EGFR and the appropriate HLA class II molecule.
In view of this, we studied whether the EGFR875 889-reactive CD4 T-cEGFR875 889-reactiveeCD4y recognise HLA-DR matching EGFR-positive HNSclonesls as APcould
However, CD4 T-cell clones M8, T8, and S22, which were efficient in directly recognising endogenous processed epitope on tumour cells, were not able to recognise tumour cell lysates presented by DCs (data not shown).
However, it has now become clear that the behaviour of the immune system is greatly influenced by signalling between interacting cells, including cells that do not directly recognise antigens [ 1- 3].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com