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Chronic stress, potentially through the actions of corticosterone, is thought to directly impair the function of immune cells.
On the other hand, it has been shown that protein aggregates can directly impair the function of the ubiquitin proteasome system (Bence et al. 2001).
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It has been reported that aggregated protein directly impairs the function of the ubiquitin-proteasome system [ 19, 20].
Mutations that directly impair the development and/or function of alveolar macrophages [50], as well as mutations that inhibit degradation of surfactant within these cells, have been shown to result in alveolar proteinosis and pulmonary dysfunction in both mouse and human [51].
The mutations in the active site of subtype AE directly impair the interactions with the inhibitor.
Alternatively, the mutant NOTCH3 may impair the functioning of astrocytic endfeet, the output end of the panglial syncytium, directly.
"Mistrust between market participants or of market benchmarks can also impair the functioning of specific markets".
Smoking can impair the functioning of the esophagus's sphincter muscle and increase your risk of GERD.
Instead, there is none.This points to the idea that the tangles and plaques may not directly impair brain function after all.
Cancers associated with major organ systems, such as the lung or the kidney, are more likely to directly impair organ function.
However, diverse clinical presentations of NRXN1 mutations in patients raise the question of whether heterozygous NRXN1 mutations alone directly impair synaptic function.
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