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Only 8% of Type 2 mutations were predicted to directly disrupt the pVHL-HIFα interface, compared with 33% of Type 1 mutations, suggesting that a direct disruption of HIFα binding may not be necessary to cause PCCs and that an HIF-independent mechanism underlies the pathogenesis of PCCs (further material in Supplementary Material, Discussion).
Today's techno-illumination can directly disrupt these complex and critical circadian cycles and directly impact health.
The flaw of control frames can be exploited by attackers to carry out DoS attacks and directly disrupt the availability of the wireless networks.
In agreement with a role for sleep disruption in headaches cluster headache (CH) patients complain of reduced sleep amount – that is complicated by the presence of consistent nocturnal attacks that may directly disrupt sleep.
If a technology can directly disrupt your business, then the cost of being too early is worth it, because the downside risk that the technology takes off before you can ride the wave is too high.
The bill has several troubling elements, those that matter most its current state however, are the three that directly disrupt Dodd-Frank.
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Together these findings indicate that silencing DNp09 neurons directly disrupts freezing, rather than indirectly affecting freezing behavior by increasing the speed of locomotion.
These loci correspond to regions targeted in prior reports22,30 or to intergenic regions, to avoid directly disrupting native coding sequences (Supplementary Tables 1 and 2).
Glare can produce discomfort, which may cause drivers to squint or avert their gaze, and can also cause disability in terms of directly disrupting visual perception.
In addition, transmission electron microscopy (TEM) analysis indicated that the surfaces of the treated pathogens underwent obvious morphological changes compared with the untreated controls, suggesting that this antimicrobial peptide exerts its action by directly disrupting membranes of microorganisms.
Third, it is conceivable that human activities, such as invasions of tribespeople from the hills to the west of the Indus valley, perhaps even Indo-Aryans, contributed to the breakdown of Indus external trade links or more directly disrupted the cities.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com