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This indirect evidence combined with the present data, suggest that further invasive assessment of the intrinsic atrial contractile properties is warranted, to establish the concept that ageing can directly blunt atrial mechanical function.
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Mechanistically, we show that Chop directly blunts Tbx21 transcription, thereby impairing T cell effector immunity.
Current medical therapies target individual pathogens with antimicrobial agents or directly either blunt or boost the host's immune system.
Asked if Mr. Cuomo should engage Mr. Paladino more directly to blunt any momentum gained since the primary last week, he said Mr. Cuomo should more explicitly tell voters how he would govern.
A pulmonary contusion is usually caused directly by blunt trauma but can also result from explosion injuries or a shock wave associated with penetrating trauma.
A minor fraction of antibodies is able to blunt infections directly by blocking essential mechanisms of attachment, entry or uncoating of intracellular pathogens like viruses [10].
The 938 and 992 bp BoHV-4IE1 left and right arm amplicons were firstly inserted in pJET1.2, a commercial vector from Thermoscientific, designed to directly subclone blunt-ended PCR amplicons (as those generated by Pfu polymerase amplification), using the CloneJet PCR Cloning Kit (Thermoscientific), generating pJET/IE1left and pJET/IE1 right.
Both FFA and TNF-α elevation have been demonstrated to blunt insulin-induced PI 3-kinase activation directly or via the production of reactive oxygen species (45– 45).
Angiotensin II (AngII) was demonstrated to blunt insulin-induced PI 3-kinase activation (56) directly or via stimulated reactive oxygen species generation (57).
A merger would also blunt Ruhrgas's incentive to compete with E.ON in serving customers directly.
She spoke directly into the camera, her light brown hair falling to her shoulders, her face soft, her words blunt.
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