Sentence examples for directly blocking from inspiring English sources

In addition, the inhibition of ERRγ activity would also have the advantage of directly blocking gluconeogenesis.

Others are directly blocking policy because they cannot see a future for their business in a sustainable world.

Because glutamate is so central to the brain's activity, directly blocking or triggering the NMDA and AMPA receptors can be very dangerous.

Sulindac and aspirin have been shown to inhibit NF-κB signaling by directly blocking the activity of IκB kinase β (Grilli et al., 1996; Yamamoto et al., 1999).

Indeed, in the current study, we discovered a novel mechanism by which quercetin blocks IL-1 production, through the inhibition of ASC-speck formation in BMDM, directly blocking the activation of the NLRP3 inflammasome.

That is, Gd@C82(OH)22 can inhibit the WW domain function not only by directly blocking the ligand binding site, but also by indirectly distracting the binding pathway of the PRM. Figure 5: Relative binding preference.

In particular, our recent results indicate that doses of indinavir or saquinavir similar to those employed to treat AIDS patients can induce regression of experimental KS by directly blocking two fundamental steps of KS initiation and progression: new blood vessel formation (angiogenesis) and KS tumour cell invasion.

In summary, three Grb proteins can inhibit IR activity by directly blocking downstream signaling.

The authors however observed the stages of (a) blocking of the smallest pores by all particles, (b) covering of the inner surfaces of bigger pores, (c) superimposition of some particles on already present particles with some others directly blocking some of the pores, (d) then the initialization of cake build-up.

Attempts to control house sparrows include the trapping, poisoning, or shooting of adults; the destruction of their nests and eggs; or less directly, blocking nest holes and scaring off sparrows with noise, glue, or porcupine wire.

Overall, our results suggest that vardenafil reverses ABCB1-mediated MDR by directly blocking the drug efflux function of ABCB1.