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Factor Xa can also directly activate cells via PAR-1-mediated cell activation [ 135].
In human muscle, calponin can directly activate PKC autophosphorylation that increases PKC activity [ 15].
Higher concentrations directly activate the receptors.
Thus, OsMYB86L and OsMYB61L directly activate the transcription of OsCESA4, OsCESA7, and OsCESA9.
The Ca2+ bound CBL proteins directly activate their interacting CIPK (CBL-interacting protein kinase) proteins.
In addition, PI3K might also directly activate PAK1.
However, the AVE does not directly activate forebrain differentiation.
Alternatively, DISC can also directly activate these effector caspases [6].
Whether IL-2 can directly activate Tregs in vivo remains to be determined.
In turn, these kinases directly activate the effector kinases Chk1 and Chk2.
As a phorbor ester, TPA can directly activate protein kinase C [14].
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