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This threshold could be represented by the ligand concentration at which there is no more asymmetry in the ligand distribution in the environment around the cell and consequently no directional indication.
As in the MA.12 trial, there was a general directional indication that univariate DFS was better with higher ER and PgR, although there appeared to be no difference after 10 years follow-up, and overall there was no significant effect of ER or PgR on DFS found by qPCR or IHC assay methods, with or without statistical standardization.
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Originally intended for the college classroom, "The Lonely Crowd" unaccountably landed on the best-seller lists and stayed there for months and months as thousands of Americans anxiously examined themselves and their neighbors for directional indications.
Directional system Indication of current location Identifiability 8. How much effort did it take to identify your current location on your wayfinding aids?
No indication of directional bias for HrU10 mutations was found in tree swallows with 7 (47%) expansions and 8 (53%) contractions (binominal test: P = 1.0).
A trend towards brain expansion is assumed to have occurred throughout primate evolution [ 6] and this has been interpreted as an indication of directional selection on cognitive abilities, due, for example, to arms races in social cognition [ 7, 8].
N. terricola, which is the only homothallic taxa included here that lacks mat A-3, has a stop codon disrupting the ORF in mat a-1, suggesting that this protein does not function correctly in this taxon, and we have no indications of directional selection in the N. terricola mat a-1 gene to change function.
When a vehicle makes the transition from tail to non-tail in one of its directional sectors, it is an indication that there is now connectivity to farther vehicles in that direction and that previously stored messages can be relayed.
We found that red-arm colors had evolved independently 31 times among our sample species, while a mean of only 5.5 independent origins would be expected under random-walk evolution, an indication that strong directional selection had shaped the distribution of floral colors among our sample species.
Good precision and responsiveness are thus essential in order to quickly detect any directional change and provide reliable and rapid indications of clinically meaningful changes that would require medical intervention.
The low FST is an indication that balancing or species-wide directional selection has taken place at the CYP2C19 locus, in contrast to the force of geographically-restricted directional selection that leads to high FST values.
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