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Given the unexpected direction of the interaction of smoking with BMI, we attempted a direct replication of this finding using data from the independent ESTHER cohort, in which we had first described the smoking × alcohol interaction [13].
Intuitively it seems natural to first allow COV to decide which genes interact and then to let MSA determine the direction of the interaction; however, either order is technically feasible.
The sign of the Pearson shows the direction of the interaction.
The interaction effect may enhance or reduce the expected manifestation of overall QTL effect depending upon the degree and direction of the interaction.
Data were analysed with mixed model ANOVAs that included GS and PA as fixed factors for the general model, and GS, PA and type of interaction (MM, MU, UU, UM) to determine the direction of the interaction in the case of heterogeneous groups.
Our results suggest a prominent role of density in driving the direction of the interaction between L. pipiens tadpoles and Ranavirus.
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In addition, in the majority of the cases we were also able to correctly identify the direction of the interactions.
Finally, because of the direction of the interactions, borderline significance, and relatively few nonobese diabetic participants, we cannot exclude the possibility that these interactions are due to chance.
Table 3 presents a summary of these estimates for the country.> As can be seen from the table, spatial interaction is quite common in India's health system, although the strength as well as the direction of the interactions seem to vary widely in the country.
However, the direction of this interaction suggests the high schizotypy group (M=25.93%, SD: 9.89%) were less accurate than the low schizotypy group (M=32.15%, SD=9.18%) for fearful faces only.
In this case one does not have to invert the directions of the interaction arrows.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com