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A general measure of the goodness of a predictor is the gradient of risk per standard deviation, which is the relative increase in the hazard function when the value of the variable is changed by 1 standard deviation in the direction of risk.
The direction of risk at these SNPs is the same as in the case control analysis (Table 3).
Although the magnitude of risk may be overestimated, the direction of risk associated with intensive glycemic control is valid.
The magnitude and direction of risk did not change for any specific CA upon adjustment for sociodemographic and maternal factors.
For consistency in direction of risk comparisons, we used the odds ratio to assess the magnitude of risk for rosiglitazone use compared with that for pioglitazone use.
However, it is important to note that the magnitude and direction of risk and the gene identified are similar in both studies.
Similar(48)
The primary differences seen between our groups of largely postmenopausal women vs largely premenopausal women were differences in magnitudes rather than directions of risk.
All 4 SNPs had the same directions of risk as reported in the previous GWAS study [10] although the rs630014 polymorphism was not statistically significant, possibly due to insufficient statistical power.
We hypothesized that: ΔPR for each cancer would be significantly associated with PGT risk estimate at both follow-up time points; directionality of ΔPR would reflect direction of PGT risk estimate relative to average population risk; magnitude of ΔPR would attenuate with time; and the effect of PGT risk estimate on ΔPR would be modified by baseline participant characteristics.
It is however difficult to conceive how a risk modifier can completely invert the direction of the risk; it was in fact the A nucleotide that was reported to be associated in other South East Asian populations (e.g. Bangladesh and India).
It is also important to note that the current study was not designed to correlate specific risk factors to cardiovascular outcomes or the direction of the risk factor cardiac event relationship but was powered sufficiently for its primary objective of detecting ethnic differences in adiponectin.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com