The difference in distribution profiles confirms that WT STA cells directly migrate in the direction of protrusions without the necessity of external cues, while PTEN disruption or PI3K1/2 deletions diminished such coordination between cell polarity and cell migration.
If LUCA was a (nearly) minimal free-living organism, subsequent evolution in each lineage should have generally proceeded in the direction of increasing complexity and, by necessity, would have been dominated by gene gain, via HGT and, to a lesser extent, "invention" of new genes.
Stalin had said that honest diplomacy was like dry water, and while lies might remain a diplomatic necessity, the real direction of policy could no longer be concealed for long.
In endoscopy it is usually desirable to have a wide field-of-view (FOV) in order to be able to inspect as much as possible without the necessity of continuously adjusting the direction of the tip of the endoscope.
Nakanishi: I'm not responsible for determining the direction of the franchise itself, but I do believe that horror is an absolute necessity in the core experience of Resident Evil.
Hume develops Locke's empiricism in the direction of its sceptical implications, resulting in rejection of the existence of God, immutable moral truth and causal necessity.
The first necessity was to bring order into the chaotic methods of financial administration that were then under the direction of Nicolas Fouquet, the immensely powerful surintendant des finances.
Direction of travel (heading).
This direction of research however can be viewed as somewhat removed from real-world considerations and increasingly many academics in the field agree over the necessity of returning to foundational economic issues.
Life at sea is of necessity the being controlled by others, by the captain of the ship or the regulation of the watch, by the motion of the waves and the direction of the wind.
