Exact(2)
The determination of haplotype sharing may represent the future direction of linkage analysis due to its better adaptation to high-density SNP genotype data [2].
Direction of linkage phase for each marker with the previous marker was set to positive (coupling) or negative (repulsion) with 0.5 probability, and this process was repeated across each chromosome.
Similar(58)
In addition, 16 cases where one individual was a clear outlier relative to the others were observed, as well as 40 cases where deviations from 50 50 were always observed to a similar magnitude but in both directions (consistent with loss of linkage disequillibrium between an eSNP and the transcribed SNP).
Using this M. truncatula map and the derived F3 populations, we were able to map the Mtsym6 symbiotic gene on linkage group 8 and the SPC gene, responsible for the direction of pod coiling, on linkage group 7.
LG1 and LG6 appeared to have adverse orientations with the peach chromosomes (Ch6 and Ch8), which were nominal since, there was no stringent direction of the markers during linkage mapping.
10 Relative risks can be biased and the direction of effects even reversed, 11 as linkage success is better for healthier subgroups of the population.
In this case, information in the tree is contained in the branch direction, in the pattern of linkages between branches and nodes or, in other words, in its topology.
Elastin acts as a structural lattice over the FBN deposition, thereby determining the direction of zonular fiber growth by cross-linkage (Streeten 1982; Kielty et al., 2001; Sherratt et al., 2001; Kuchtey and Kuchtey, 2014).
An alternative explanation, however, is that evolution can sometimes be constrained by antagonistic genetic correlations (i.e., genetic correlations among traits that are not in accord with the direction of selection [ 26, 27]) arising from linkage disequilibrium between alleles at different loci, and patterns of linkage disequilibrium can vary among populations or seasons [ 28, 29].
Read that again to savor its import: that is the principle of linkage.
Olson echoed this, noting that there's a precedent for making this sort of linkage.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com