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Both p105 and Ci contain a natively disordered region immediately prior (in the direction of degradation) to the domain where unfolding and degradation stalls.
In line with this idea, it has been shown that (1) N-extended epitopes are efficiently processed by the immunoproteasome and serve as better substrates for antigen presentation (Cascio et al., 2001) and (2) the presence of a disordered region determines the direction of degradation, which in turn determines the spectrum of generated peptides (Berko et al., 2012).
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In the wild type, the POP2 enzyme is probably favoring the general equilibrium between GABA and SSA in the direction of GABA degradation, even when SSA is in high excess, like in plants grown on high amounts of SSA.
Assays to assess the activities of phenol oxidase and peroxidase have been developed to predict the degree and the direction of phenolic degradation.
This observation suggests that DNA methylation is a key regulatory step in the shift in the balance of cartilage maintenance in the direction of overall degradation.
Positive correlations reflect the 5'-end to 3'-end direction of mRNA degradation whereas negative correlations result from the compensatory increase in stable and 3'-end probed transcripts.
A compromised cross angle θ for CRPC lattice is chosen to enhance the coupling strength in the transverse direction without degradation of single longitudinal mode performance after numerical simulation.
Patients in cluster 1 mainly displayed a decreased degradation of primary necrotic chromatin, which points in a direction of a separate mechanism of degradation and aligns with previous reports describing cofactor-dependent degradation of the highly condensed chromatin from primary necrotic cells that require decondensation before efficient degradation.
We focused on metabolic enzymes because of their similar direction of effect on warfarin -- degradation.
Overall, together with a useful mycobacterial compendium of phenotypic and genomic properties, the apparent lifestyle-dependent phenotypic connection of the MPN provides global insights into the direction of phenotypic evolution, including PAH degradation, in the genus Mycobacterium.
An additive effect with regards to erbB2 degradation and anti-tumour activity was observed in geldanamycin/CI-1033 geldanamycin/CI-1033nts, whicombination thexperimentsypothesis that these inhibitory agents act on different components of the chaperone-receptor complex in their direction of erbB2 to a common degradation pathwhich
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com