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Co-author Richard Smith, a computer scientist at Max Planck Institute for Plant Breeding Research in Germany, created the MorphoGraphX software used to measure the growth rate and growth direction of cells.
We compared computer simulations to experiments by examining projection direction of cells exposed to microfluidically-generated gradients [ 50- 52].
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Directional motility was measured as an angular value between the direction of cell taxis and a fixed reference point at the edge of the Petri plate.
Carter, S. B. Principles of cell motility: the direction of cell movement and cancer invasion.
OFT myocardialization was disrupted with cardiomyocytes failing to align with the direction of cell invasion into the outflow cushions.
Another major research interest is multivalency and its role in recognition, signal transduction, and direction of cell fate.
One of these, involving the atypical cadherins Fat and Dachsous and the ectokinase Four-jointed, appears to link the direction of cell polarization to the tissue axes.
In particular, the speed and direction of cell crawling, as well as the rate of cell proliferation, vary with the substrate compliance and prestrain.
These continuous zigzag microchannels can guide the direction of cell movement even for cells with altered intracellular signals that promote random movement.
The direction of cell alignment was dependent on the scale of the topographical cues and, to less of an extent, the culture medium.
Components of the extracellular matrix can localize and modify growth factor signals, and by doing so impart instructional stimuli for direction of cell phenotype.
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