"directing integration" is a valid and usable phrase in written English.
It is typically used in the context of business or organizational management to refer to the process of coordinating and organizing different systems or departments into a cohesive whole. Example: The CEO is responsible for directing integration of the company's marketing and sales departments to improve overall efficiency and effectiveness.
One approach to directing integration into predetermined DNA sites is fusing IN to a sequence-specific DNA-binding protein, which results in a bias of integration near the recognition site of the fusion partner.
To provide evidence for a role of the MLV integrase in directing integration to TFBS-rich regions, we carried out a comparative analysis of the sequences flanking the integration sites of an MLV vector [3], an HIV vector [19], and an HIV vector packaged with an MLV integrase (HIVmIN) [19], in HeLa cells.
Another approach to directing integration is to fuse integrase with a sequence-specific DNA-binding protein, which results in a bias of integration in vitro into the recognition site of the fusion partner.
Lentiviral integration is favored in active transcription units, which allows efficient viral gene expression after integration, but the mechanisms directing integration targeting are incompletely understood.
Relevant analytical results are compared, for validation purposes, to direct integration of the reference and reduced models.
The ability of BER to direct integration to chromatin targets remains to be tested.
Digestion with Bsu36I directed integration into TRP1, which is intact in the BY background, and integration was selected using HygR.
Further, analysis of the production levels could confirm that site directed integration significantly reduces the variations of clonal expression levels.
This plasmid permits the generation of DNA fragments that can direct integration of P tcu-1 into any desired locus.
On the other hand, their characteristic vertical geometry and fabrication strategy hinders a direct integration within integrated circuits.
The third suggested technique is named the direct integration technique.
