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The goal of our research is to uncover novel mechanisms governing the assembly of the ECM protein fibronectin and its role in directing assembly of other ECM proteins to form a definitive matrix.
They are involved in translation initiation, tethering of translating ribosomes to the membrane, and directing assembly of newly synthesized proteins into multiprotein complexes (Table 1).
This result argues against the current model in which piRNA PIWI protein complexes silence transposons in ovarian tissues by directing assembly of heterochromatin-like domains.
In the present study, we present a new example where a bacterial amyloid-like self-assembly plays an important role in directing assembly of Hfq into supramolecular cellular structures that includes other components of the RNA processing and degradation pathway.
Exploiting the natural mechanism of protein accumulation in seed PBs, we demonstrate that not only is the Zera domain capable of directing assembly of PB-like organelles in plant tissues other than seeds, but this assembly property also extends to a broad range of non-plant eukaryotes including fungal, insect and mammalian cells.
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As for directed assembly, we will record, catalogue and disseminate the methods and future directions that can enable the controlled disassembly of suitably designed condensed materials for the range of building blocks considered above.
Yazdani F. Design and direct assembly of 2.5D/3D rigid silicon interposer on PCB.
Glasmacher, E. et al. A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes.
Huang, Y., Duan, X. F., Wei, Q. Q. & Lieber, C. M. Directed assembly of one-dimensional nanostructures into functional networks.
Desai, A. et al. KNL-1 directs assembly of the microtubule-binding interface of the kinetochore in C. elegans.
Tsuruda, P. R., Julius, D. & Minor, D. L. Jr. Coiled coils direct assembly of a cold-activated TRP channel.
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