In our practice, once a patient is admitted to the trauma bay, whatever their haemodynamic status, the protocol will direct them for a WBCT scan for an exhaustive injury assessment, before or after an emergency haemostatic intervention (surgery or interventional radiology).
Since these would be damaging if they mixed freely with the remainder of the cytosol, the barrel is capped by a set of regulatory proteins that recognize proteins with a signal directing them for degradation (a ubiquitin tag) and feed them into the proteolytic cavity.
COP1 directly interacts with target proteins and directs them for degradation (Hoecker, 2005; Jiao et al, 2007).
It would be advantageous to use the tool as a preliminary step to identify patients at high risk and to direct them for treatment (and research) purposes.
In the cytosol, another suite of chaperones, such as Hsp70, Hsp83, Hsp40, and Hsp23 recognize hydrophobic patches of misfolded proteins and may either refold them or direct them for further proteasome degradation [ 125].
Whereas the most studied class of miRNAs are ~22 base long ribonucleotide sequences that target complementary untranslated regions of mRNAs, directing them for degradation in the RNA-induced silencing complex, or regulate their translation, other noncoding RNA types have different or less understood mechanisms of action.
It said Mr. Dincman had directed them to apply for a United States passport and, after receiving it, report it lost so that they could obtain a duplicate.
Whether the candidate knew about these misdeeds, or whether he directed them, are matters for the courts to determine.
