Sentence examples for directed substantially from inspiring English sources

Toxic effects of anti-CD22 therapeutics are thus directed substantially against the mature B-cell pool, reducing myelotoxicity.

"[D]uring his lifetime, he will gift or otherwise direct substantially all of his shares of Facebook stock, or the net after-tax proceeds from sales of such shares, to further the mission of advancing human potential and promoting equality by means of philanthropic, public advocacy, and other activities for the public good," the company said in the filing.

Her innovative teaching practices, leadership, and extensive work in action research has substantially directed best practices in graduate level teaching methodologies and student mentoring programs.

So, I think that regulation of finance, financial markets, and institutions is substantially directed at dealing with psychological problems, and the tendency for some people to exploit human weaknesses, and manipulate and take money from other people rather than help them.

CONCLUSIONS: These results suggest that the scope of directed evolution is substantially larger than previously envisioned in that it is possible to perturb the active site residues themselves as well as surrounding loops to alter specificity.

The CM79 site, a surface-exposed conformational B-cell epitope comprising the C-terminus and an internal sequence of CP has been identified by this method and we have shown previously that the human antibody response to CP is substantially directed towards this CM79 site.

As indicated in (Figure 1Cv) siRNA directed against HIF-1α substantially reduced expression of ALKBH5 whereas siRNA directed against HIF-2α resulted in a modest, but statistically insignificant increase, of ALKBH5 mRNA.

Perioperative goal directed therapy (GDT) can substantially improve the outcomes of high risk surgical patients as shown by many clinical studies.

The strong sequence diversity demonstrated here suggests that instead phosphite oxidation is likely an old activity, and the very similar catalytic parameters, combined with the inability to increase kcat substantially by directed evolution, suggest that the rates of oxidation of phosphite by PTDHs may be limited by a relatively high intrinsic barrier.

Officials were directed to not renew or substantially downscale contracts with prison operators as they expire.

In addition the mean flow velocities are comparable, yielding a substantially larger offshore directed sediment transport capacity.