Sentence examples for directed repression from inspiring English sources

Here, we provide evidence of a second mechanism of WG/WNT directed repression, namely Direct Repression [44].

Repression of both the 10 kb and 2.8 kb (APRD) dpp reporters is lost in the ventral region of wgts discs within 24 h of a temperature shift, indicating that the APRD region of the dpp enhancer is responsive to WG directed repression (Fig. 2A,B and data not shown).

To determine whether repression by WG signaling is direct or indirect and to better understand the factors that allow a WG signal to be inhibitory, we investigated whether dTCF binds to the dpp gene and whether dTCF and/or ARM are required for WG directed repression.

miR-203 regulates the epidermal keratinocyte differentiation and directed repression of p63 expression [ 12, 13].

Alternative transcript splicing and polyadenylation can eliminate miRNA regulatory sites from a message, and miRNA directed repression can be blocked by certain RNA binding proteins.

As it functions as a key negative-feedback regulator of conidiation, vosA is necessary and sufficient to direct repression of brlA and development.

Functionally, JMJD2A could interact with histone deacetylase (HDAC) and retinoblastoma protein (pRb) and could direct repression of E2F-responsive promoters [ 21].

Furthermore, DNMT3L is able to recruit histone deacetylases through its PHD zinc-finger-like motif and possibly directs repression onto newly established imprints (Aapola et al. 2002; Deplus et al. 2002).

Despite the lack of Hdac1 binding to her6 promoter sequences, this gene remains a candidate direct target for direct repression by Hdac1, as Hdac1 repressed her6 expression in restricted regions of the CNS from 12 hpf onwards.

MicroRNA (miRNA) directed gene repression is an important mechanism of posttranscriptional regulation.

Tbx16 locks cells into the mesodermal state by not only activating downstream mesodermal genes, but also by repressing bipotential progenitor genes, in part through a direct repression of sox2.