Sentence examples for directed efficient from inspiring English sources
We show the design of an LpxC inhibitor utilizing a robust model which directed efficient design of picomolar inhibitors.
The modified guide (EL3'-11dT) direfficienticleavageeavage in cell extract (lane 5) and was stable in cell extract for up to 2 hours while unprotected EL3'-11 degraded after 10 minutes (data not shown).
A phage integrase directs efficient site-specific integration in human cells.
We previously isolated the human EC-binding peptides SIGYPLP and LSNFHSS by phage display and demonstrated by means of a bispecific antibody that SIGYPLP directs efficient, high-level, EC-selective Ad-mediated gene transfer.
Both gRNAs were able to direct efficient C T conversion on the non-target strand in the target region (Fig. 2C and 2D), and to a lesser extent, C G/A conversion (Figs. 2C, 2D, and S1).
This motif is distinguished from the well-known Kozak in its unique ability to direct efficient and accurate translation initiation from mRNAs with a very short 5'UTR.
IRES elements found within the 5' untranslated regions (UTRs) of picornavirus genomes have been extensively studied for this purpose and are able to direct efficient translation of a downstream ORF within a discistronic mRNA within mammalian cells [8].
This analysis showed that the 17 adenosines positioned upstream of the MC4R DSE can direct efficient cleavage independently of the presence of upstream UGUAN sequences.
Therefore, there is a need for novel biochemical screening tools to identify and direct efficient genetic analysis in those for whom a probable monogenic diagnosis of diabetes exists.
In contrast to the PAPOLG poly(A) site, the MC4R DSE can direct efficient cleavage downstream of an A-rich sequence independent of the four UGUAN sequences in its 3′UTR.
