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This study exemplifies the era of human reverse clinical genomics ushered in by large disease-directed cohort studies; first defining a new syndrome molecularly and, only subsequently, phenotypically.
Roberts BW, Kilgannon JH, Hunter BR, Puskarich MA, Pierce L, Donnino M, Leary M, Kline JA, Jones AE, Shapiro NI, Abella BS, Trzeciak S. Association Between Early Hyperoxia Exposure After Resuscitation From Cardiac Arrest and Neurological Disability: Prospective Multicenter Protocol-Directed Cohort Study.
If newborn cohort studies took direct measures into consideration in addition to interviews and questionnaires, they often relied on the Bayley Scales of Infant Development (Bayley 2006; Schlesiger et al. 2011 for a brief overview).
Direct estimates are available from cohort studies.
Larger cohort studies including direct patient interviews to further define the implications and to address the impact of this strategy of SFs results return are warranted.
Limited cohort studies provide more direct evidence but still have not been able to establish a causal relationship [ 14].
This paper focuses on findings from a review of cohort studies that provided direct evidence on dissemination bias by investigating the association between publication and study results.
Last, as with many cohort studies in the ICU, mortality is not always the direct consequence of the initial problem.
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