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One-hundred forty-five (65.6%) of 221 trials of disease-modifying agents registered in the 2002 through 2012 period were directed at this target.
As FIH hydroxylates a specific target residue within a large peptide (CTAD-Asn), our focus was directed at this target residue pocket, formed by the side chains of FIH residues Tyr, His, Arg, and Gln.
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Cancer therapies directed at these targets would be expected to provoke muscle wasting and this was shown for sorafenib (Antoun et al, 2010).
However, compounds directed at these targets have yet to be developed.
In the present study the attention was maintained directed at the targets for several seconds, allowing for the BOLD effect to build up.
Despite this well-documented association, few current treatment options for dementia are directed at this potential therapeutic target [45].
This air attack, directed at Serbian targets in the spring of 1999, was the largest ever launched by NATO in its 50 years of existence.
This statement was directed at previous targeted metabolomics studies of the intestine in which intracellular material was also analyzed from sonicated fecal samples.
This assumes that each side's weapons are directed at military targets: Many more people could be killed, with far fewer weapons, if population centers were made the principal objective of an attack.
The iconoclasm, though, was directed at different targets.
Eighteen were directed at Taliban targets in Pakistan, and fifteen were aimed specifically at Baitullah Mehsud.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com