Several studies also measured the pharmacological effects of intranasally delivered molecules, thereby strengthening the possibility of a direct and efficacious nose-to-brain transport also in humans [38].
ROTEM-guided haemostatic therapy with fibrinogen concentrate as first-line haemostatic therapy and additional use of PCC was goal directed, efficacious, and quick to administer.
In conjunction with advances in PRRSV molecular virology, reverse genetics and immunology, more and more attention is being directed to development of safe and efficacious vaccines against PRRSV.
Currently there are no available licensed vaccines or antivirals for dengue, although significant effort has been directed toward the development of safe and efficacious dengue vaccines for over 30 years.
Understanding physiologic factors driving insulin resistance in endotoxemia may direct efficacious glucose control strategies during inflammatory states.
Direct mucosal administrations of soluble antigens only elicit relative low immunogenicity, thus safe and efficacious mucosal adjuvants are often co-administered with antigens to increase immunogenicity of non-living vaccines (De Magistnis, 2006).
12 Bevacizumab (Avastin, Genentech, Inc ., a humanised monoclonal antibody directed against VEGF, is efficacious for treating ME following BRVO.
In conclusion, given greater awareness of the advantages offered by the minimally invasive direct anterior approach, we have tried to validate a minimally invasive surgical technique as a safe and efficacious means of reducing morbidity and accelerating functional recovery.
It needs to be safe, valid, reliable, useful, and efficacious.
And yet this is the most influential, and efficacious, royal portrait in British history.
