Sentence examples for direct translocation from inspiring English sources

One of the most interesting characteristics of functionalized CNTs (f-CNTs), from a drug delivery point of view, is their ability to translocate across plasma membranes and enter the cells either passively by direct translocation across membranes or actively via endocytosis [2].

Endocytosis and direct translocation through the membrane are the generally accepted routes.

Uptake mechanism studies demonstrated that direct translocation, caveolae-dependent endocytosis and macropinocytosis were involved in the internalization of [Arg17]PACAP(11 38).

Chaperone-mediated autophagy (CMA) involves direct translocation of unfolded substrate proteins across the lysosome membrane through the action of a cytosolic and lysosomal chaperone hsc70, and the integral membrane receptor lysosome-associated membrane protein type 2A (LAMP-2A).

We propose a model for membrane-associated insertion/folding and exit/unfolding and discuss the importance of these observations for the design of new delivery agents for direct translocation of polar therapeutic and diagnostic cargo molecules across cellular membranes.

We can only suspect that the measured EA came from a Gram negative component of infection, which was either not revealed in microbiological tests or it was caused by direct translocation of endotoxin due to sepsis-induced permeability of the gut.

Taken together, data herein have established that the hIP undergoes significant time-dependent internalization in response to cicaprost stimulation; over-expression of Rab5a increases that internalization; the internalized hIP co-localizes to Rab5a positive endosomes and agonist stimulation leads to direct translocation-dependent activation of Rab5.

To our knowledge, the current clinical literature describes only one study including evidence of direct translocations of E. coli from the bowel to the circulation and which involves newborns with urinary tract infections [ 20].

This N-terminal signal peptide directs translocation of the pre-α-CGTase across the inner membrane to the periplasmic space via the SecB pathway (Su et al. 2012).

The LEE-encoded T3SS directs translocation of NleA into host cells, where it localizes to the Golgi apparatus [39].

Consisting with previous work[27], our study confirms again the hydrophobic domain (residues 112 135) acts as a type II signal-anchor sequence, directing translocation of the C terminus across the membrane to produce Ctm-PrP.