Sentence examples for direct the modification from inspiring English sources

These characteristics may direct the modification of histone and further the activation or silencing of target gene [ 11].

In this or a similar context, stimulation of PARP-1 sumoylation by association with intact DNA would help to direct the modification to chromatin-associated molecules.

Much work has been done to elucidate the frans-acting proteins that lay down different epigenetic modifications; however, very little is known about the cis regulatory regions that direct the modifications to their targets.

First, the application of the SAMDI method to biochemical assays of HDAC activities and, by extension, to other activities directed toward the modification of histones provides a straightforward and flexible route to characterizing and comparing the activities of members of this important family of enzymes.

Following the symmetry argument in Crick's model for maintaining modifications, the symmetrical pairing of the four core histones (for example, two histone H4 subunits, two H2b subunits, and so on) in a nucleosome might direct the re-modification of hemi-modified histone pairs in nucleosomes.

If the histone-modifying enzyme directs the histone modification, its perturbation should cause a differential change in expression of modification cohort genes.

Among the various modifications investigated, the direct modification of the bead surface with linear heterobifunctional PEGs, consisting of 23- and 60 PEG-units significantly reduced the background binding.

In other words, the direct modification of the entity does not change the endurant property of the entity.

Despite no magnetic enhancement can be observed within the Grafenberg LPS, environmental magnetic parameters combined with selected geochemical analyses (Sr/Rb) provide direct information on the modification of silicates and magnetic minerals in the course of pedogenesis and diagenesis.

These structural changes, rather than the direct modification of the active site Cys residue, are the source of UV-induced inactivation.

At the CB the scaRNA binds proteins forming a scaRNP, which then directs the direct modification of the snRNA component of the snRNP by 2′- O-methylation and pseudouridylation.