Sentence examples for direct the altered from inspiring English sources

This profound phenotypic conversion from an epithelial phenotype to a spindle-shaped morphology is orchestrated by integrated networks of signal transduction pathways and EMT-related transcription factors (TFs) that direct the altered expression of genes involved in cell adhesion, differentiation and motility.

Hence, the current observations should be considered a direct consequence of the altered frataxin protein levels rather than altered DNA structure and/or triplet repeat formation.

miRNA mimic (hsa-miR-125b, hsa-miR-27b, hsa-miR-93, hsa-miR-20a) and inhibitor (hsa-miR-1224-3p, hsa-miR-1260 hsa-miR-1260 hsa-miR-1260approachled the direct inforence of the altered metaselects in the regulation of identified protein targets.

We failed to show a direct interrelation between the altered hormonal status and bone density and metabolism, confirming results in primary male osteoporosis, where E2 deficiency in 14/42 (33%) men did not correlate with BMD [ 26].

Further, we performed miRNA-target analysis, comprehensively identified the alterations in the expression and cellular localization of the target proteins in ex vivo and in vivo metastatic cells, recognized the direct influence of the altered miRNAs on the regulation of target proteins with mimic/inhibitor approach, and compiled the target proteins' association with neuroblastoma patient outcomes.

However, LXRE binding by both LXRα PPARα and LXRα RXRα heterodimers was weakened by the addition of LCFA, suggesting either a direct consequence of the altered PPARα affinity for LXRα or an altered affinity for DNA in the presence of LCFA.

We show that the altered migration is a direct function of MMP-2 regulation.

Relying heavily on Hal Charney, chief of computer support services, Mr. Stancik said, Ms. Lazar directed the altering of attendance sheets submitted by teachers.

Because the only reported function of σE is to direct transcription, altered regulation of one or more of the genes in the σE regulon should ultimately lead to bleb formation and loss of viability when σE activity is blocked.

Direct regulation, altering the informational environment, and altering the built environment are the least costly, most logistically feasible, and most effective noise reduction interventions.

Thus, changes in ciprofloxacin accumulation in the presence of diclofenac, and perhaps salicylate, may not be the direct cause of altered susceptibility to ciprofloxacin and other fluoroquinolones.