Sentence examples for direct suppression from inspiring English sources

Moreover, inhibition of p38 MAPK or Mdm2 partially reduced U18666A-induced increase in RhoA and significantly suppressed ROCK activation, indicating that, in addition to direct suppression of ROCK, p53 may also inhibit the local translation of RhoA.

By showing the direct suppression of PTC growth and dome formation treated with heparinase, we demonstrated that the interaction between cell surface heparin sulfate proteoglycan and chitosan played an important role in PTC proliferation and differentiation.

It has been reported that treatment with a combination of anticancer drugs (5-fluorouracil) and triterpenes (betulinic acid, ursolic acid and oleanolic acid) resulted in additive or synergistic suppression of cell growth in vitro and in the reduction of experimental esophageal squamous carcinoma cells cell metastasis by direct suppression of cell growth in vivo (Yamai et al. 2009).

By direct suppression of mitogen-activated protein kinase/extracellular signaling-regulated kinase1/2 (MAPK/Erk1/2) signaling pathway in NSCs using U0126, known to inhibit the activation of Erk1/2, we demonstrated that the enhancement of Erk1/2 pathway is one of the effects of H-UNCD-induced NSCs differentiation.

In addition, regulatory T cells impart direct suppression of effector function of autoaggressive T cells [1].

Our data also suggest that other mechanisms, such as direct suppression via gp120, may play a role in immune dysregulation.

The upmodulation of miR-17-5p mediathe the oncogenic properties of MYCN, through a direct suppression of p21 and BIM translation.

Together these data illustrate that immunosuppressive drugs and drug combinations in clinically relevant concentrations contribute to a direct suppression of T-cell function.

This suggests that either cells with lytic viral replication are particularly susceptible to rapamycin treatment or, instead, there is a direct suppression of virion production from KSHV+ cells.

Besides direct suppression of the microbial proteases, CrSPI-1 has been shown to target the host's endogenous proteases like the CrFurin.

Given the inherent redox sensitivity of T cells, we tested the hypothesis that oxidants may mediate the direct suppression of Teffs by Tregs.