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It is conceivable that MIF is a common permissive factor for other growth stimuli rather than possessing a direct stimulating activity.
This conclusion is also supported by direct stimulating effects of the heptapeptide on cultured renal cells to stimulate the activation of NF-κB and related genes.
There are reports that leptin has a direct stimulating effect on the proliferation of CD8+ cells [ 70, 71] or an indirect stimulating effect through the function of dendritic cells [ 72].
IL-7 produced in response to lymphopenia stimulates proliferation of both naïve and memory human T-cells [ 7], but also has a direct stimulating effect on thymic activity [ 11].
To rule out direct stimulating effects of AMD3100, we measured 3H incorporation in vitro in marrow cells co-cultured with various concentrations of AMD3100 or G-CSF.
In addition, these compounds have a small direct stimulating effect on sGC.
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IL-4, a cytokine with marked PM-mediated increases in gene and protein expression, regulates allergic inflammation by eosinophil adhesion and recruitment to lung airways, promotes TH2 cell differentiation, and direct stimulates airway remodeling (Kips 2001).
For direct stimulation, cells were stimulated with goat F ab′ 2 fragments of anti-human IgM antibodies (10 μg/mL) (Southern Biotech, Birmingham, AL) at room temperature.
The secreted PEG2 from MSCs also inhibits the secretion of proinflammatory cytokines and increases the secretion of anti-inflammatory cytokines by the stimulated macrophages, indicating that PEG2 directs stimulated macrophages into an anti-inflammatory phenotype [ 21].
In a Reiki session, the practitioner places his or her hands over various parts of the patient's body, with the goal of directing and stimulating the flow of "life force energy".
That's why when the members of Congress return to the Beltway, their job one must be to act as responsible fiscal policy-makers by passing legislation directed at stimulating the economy and creating good paying jobs.
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