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Multiple oncogenic processes are initiated at the cell surface, where KRAS* physically and functionally interacts to direct signalling that is essential for malignant transformation and tumour maintenance.
Altered expression of adhesion molecules, including cadherins and intergrins, permits cellular detachment from the primary tumour mass, through changes in adhesion specificity and direct signalling to intracellular pathways ('inside-out' signalling).
Amplification of inflammation during DSS through direct signalling by molecules harbouring DAMP activity via TLRs, is also supported by the increased abundance of DAMP-induced transcripts as those encoding the pro-inflammatory IL-18 cytokine or the NLRC4/CARD12 intracellular sensor [55].
Scaffolds facilitate and direct signalling to various cellular compartments [ 3].
Direct signalling from the receptors to EIN2 could conceivably represent a signalling bypass of CTR1.
MAPK and PI3K have also been implicated in TGF-β signaling and more direct signalling, both through the conventional Smad pathways and other as yet unknown pathways [ 12].
Similar(49)
For a real contact, the resonators may interact instantaneously, which requires direct signal flow in both directions between the resonators.
The simplest type of reflector is a plane reflector introduced to direct signal in a desired direction.
"This is a clear, direct signal," the Republican said.
Currently, a direct signal regulating these FIC proteins has not been identified.
System detects direct signals of neural activity; could reveal patterns underlying behavior.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com