39 40 In humans, however, direct evidence for cannabis sensitisation is lacking.
Possible mechanisms for such sensitisation include direct exposure to antigens crossing the placenta [ 11- 13] or transfer of idiotypic antibodies that cross the placenta [ 14, 15].
However, none of these studies was a longitudinal investigation into suicidal behaviour across the depressive episodes, and so there was no direct evidence of a behavioural sensitisation.
Furthermore, previous studies have identified sensitisation of TRPV4 without direct activation by other common inflammatory mediators (Alessandri-Haber et al., 2006).
Radiochemotherapy also inflicts direct injury to the tumour, facilitating selective sensitisation of the recovering immune system against tumour antigens (Asavaroengchai et al, 2002; Cho et al, 2000).
Indomethacin pretreatment may reduce sensitivity to NGF through several mechanisms, including anti-inflammatory effects in the joint, reduced afferent barrage to the spinal cord, and direct effects on glial cells that contribute to sensitisation in rat OA models.
Therefore, the premise of combining olaparib and bevacizumab is based on the rationale that direct targeting of PARP by olaparib and indirect sensitisation to olaparib by acquisition of HR defects by bevacizumab will be therapeutically beneficial, and pragmatism as bevacizumab is incorporated into standard-of-care treatments in tumour types that PARP inhibitors have potential to be effective.
Regardless, BRCA1 is an appealing target for sensitisation and screening BRCA1 mutations may help direct patients to their most optimal treatment.
23 HCWs using these gloves are exposed via direct dermal contact and are at a risk for developing latex sensitisation which maybe asymptomatic and if exposure continues they can later develop LA which presents with clinical manifestations.
First, a single exposure to IMO elicited a long-lasting sensitisation of the HPA axis that apparently was not a direct consequence of fear/anxiety elicited by the novel environment.
