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Identification of effective combination therapies is critical to address the emergence of drug-resistant cancers, but direct screening of all possible drug combinations is infeasible.
We investigated the suitability of surface plasmon resonance (SPR) for providing quantitative binding information from direct screening of a chemical library on protein tyrosine phosphatase 1b (PTP1b).
A fast and simple flow-through optosensor was designed and characterized for the direct screening of four tetracycline (TCC) antibiotics (tetracycline, oxytetracycline, chlortetracycline and doxycycline) in water and bovine milk samples.
design selective combination therapeutics as well as methods for the direct screening of therapeutic targets in patient-derived tumors.
This was achieved by direct screening of a T. parva Muguga schizont cDNA library with CD8 T-cell lines.
Animal cells have been used for the direct screening of hypermutating antibodies [11], [12] and during antibody selection from a retroviral-antibody display library [13].
Similar(40)
pipiens complex by direct screen of the Cx.
To provide a rapid and direct screen of site-directed FusB mutants for those exhibiting impaired binding to EF-G, we expressed them in S. aureus and used susceptibility testing to identify those mutants exhibiting increased susceptibility to FA compared with a strain expressing unmutagenized FusB.
Through directed screening of compounds prepared as metalloprotease inhibitors a compound, CGS 30084, that had potent endothelin converting enzyme-1 (ECE-1) in vitro inhibitory activity (IC50=77 nM) was identified.
This combined information can be very valuable for a directed screening of microsatellite markers linked to CCR in populations segregating for microfibril angle in an attempt to validate this QTL in different populations or Eucalyptus species.
Understanding these risk factors may facilitate preventive strategies and direct screening for symptoms of PTSD after critical illness.
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