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The direct responsiveness of Spot 42 levels to glucose and cAMP is due to repression of spf by a cAMP-CRP (cAMP-receptor protein) complex [ 7, 8].
The direct responsiveness of many quorum sensing target genes to receptor protein levels early in growth confirms the role of super-regulation in quorum sensing gene expression.
The first is direct responsiveness to an environmental cue (or cues) for time of year, most commonly seasonal changes in photoperiod.
Changes in the expression of cold-shock proteins (RBM3 increased, CSDA and YB-1 decreased) and the increase in histone H2A.V at 25°C potentially counteract the generalized decrease in gene expression by enhancing translation efficiency and the direct responsiveness of genes to cold, respectively.
In addition, the ability to store these compounds or their precursors in specialized leaf structures (e.g. secretory cavities or trichomes) and their inducibility upon abiotic and biotic stresses creates variance from direct responsiveness to increasing temperature or modelling their species-specific emission potential [ 20, 35].
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It features all of the playful and direct driver responsiveness you'd expect from a real sports car, but without the nervousness you might get from a down and dirty racing machine.
Strikingly, direct light responsiveness of peripheral clocks is also encountered in a vertebrate, the zebrafish.
Direct calcium responsiveness of the core machinery for oxidizing ER client protein thiols has been dismissed by our studies.
But responsibility to "the state" is impersonal - and the citizens of a democratic state may also reasonably demand from their judges direct attention and responsiveness.
However, direct hepatic insulin responsiveness was not assessed in this study.
While not a direct measure of responsiveness, these results suggest that the EPBD pain severity ratings will be sensitive to treatment-related improvements in clinical trials.
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