Tbx16 locks cells into the mesodermal state by not only activating downstream mesodermal genes, but also by repressing bipotential progenitor genes, in part through a direct repression of sox2.
There are, obviously, other means of more direct repression.
Surjit, M. et al. Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor.
A direct repression could be achieved by direct constitutive association of CNOT2 with chromatin at the MHC II locus.
It's not the consequence of either direct repression, à la Ariel Sharon, or bringing the entire Middle East structure tumbling down, à la Bush.
Czimmerer, Z. et al. The transcription factor STAT6 mediates direct repression of inflammatory enhancers and limits activation of alternatively polarized macrophages.
Here, by studying the reprogramming of mouse fibroblasts to neurons, we found that the pan neuron-specific transcription factor Myt1-like (Myt1l) exerts its pro-neuronal function by direct repression of many different somatic lineage programs except the neuronal program.
In RMS, deregulated PRC2 activity leads to constitutive expression of TBX2 which functions to drive proliferation by direct repression of CDKN1A, CDKN2A, and PTEN while inhibiting the activity of MYOD1 and MYOG27.
We present our optimized techniques and data from studies that measure specific and direct repression (i.e. negative regulation) of mRNAs by members of the PUF family of RNA binding proteins in cultured human cells.
LOC_Os11g01130 (Wox3/OsNS2) is involved in the direct repression of YAB3, which is required for rice leaf development (Dai et al.[2007]).[2007]
"In 1968, it was more direct repression," said Mexico City University political science student Josue Gonzalez, 20, as he marched at a protest against the latest attacks.
