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CTGF also might promote the direct proliferation of osteoblasts [ 14].
Cystogenesis in planarian protonephridia results from direct proliferation of protonephridia progenitors and requires the presence of stem cells.
They could also function to further activate other lymphocytes such as macrophages to further facilitate MuSC proliferation in vivo besides the direct proliferation effects of the four cytokines.
As seen from the two tables, genes responsible for proliferation are shut down in both cell lines, with NHEK showing a stronger direct proliferation effect (more genes are shut down).
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However, one study using Ki-67 showed a significant relationship between HER3 and HER4 positivity and decreasing Ki-67 levels [ 19], arguing that neither of these receptors is involved in directing proliferation.
miR-221 directs proliferation of embryonic ECs through vascular endothelial growth factor C (VEGF-C /Fms-related tyrosine kinase 4 (Flt4) signaling [ 64] that is modulated by PI3K3R1 that stimulates interaction of PI3K with VEGF-C /Fms-relatedt4 (VEGF-C /Fms-related for VEGF-C and VEGF-D [ 69].
The ability of the ECM to direct the proliferation, differentiation and function of cells implicates ECM remodeling in normal ovarian function.
Approaches to TE, RM and cancer therapy center on the necessity to deliver cell signals to direct cell proliferation and differentiation.
GATA transcription factors direct cell proliferation and differentiation in many organs, and are implicated in tumorigenesis.
Both pathways help direct proper proliferation and differentiation, embryogenesis and adulthood.
The leptin tumor-promoting effects are probably direct (cell proliferation and survival) and indirect via the regulation of molecules involved in tumor growth.
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