Sentence examples similar to direct gag from inspiring English sources

Monosialic gangliosides GM2 and GM3 accumulate in lysosomes and other organelles (such as mitochondria and Golgi bodies) secondary to heparan sulfate accumulation, 18, 52– 55 either by direct GAG-mediated inhibition of lysosomal enzymes responsible for ganglioside degradation, 56 or, alternatively, by deregulated trafficking or synthesis of gangliosides.

Demonstrates that the phospholipid PtdIns(4,5 P2 plays a central part in directing Gag to the plasma membrane.

The results demonstrate a novel mode of HIV-1 Gag downregulation by directing Gag to an intracellular site via the interaction of Gag with a gp41 cytoplasmic domain fusion protein.

Gag contains domains that are required for virus assembly and release: the matrix (MA) domain directs Gag to the plasma membrane and promotes the incorporation of the viral envelope (Env) glycoproteins; the capsid (CA) domain drives Gag Gag interactions during assembly; the nucleocapsid (NC) domain packages the viral genomic RNA; and the p6 domain is required for efficient particle release.

Antibodies directed to Gag(p17) were boosted significantly with additional immunizations, while anti-E2 responses reached a plateau.

Direct impact by Gag sequences on processing by protease was assessed by construction of chimeric Gag-Pol regions and by site-directed mutagenesis.

The tryptophan residue of the CXCL8 proteins is located at the C-terminal helix and therefore prone to direct participation in GAG binding.

The ITC results show that the interaction between drugs and GAGs is via direct binding and that GAGs bind to drugs at one set of sites.

He wanted to write gags, direct and perform them himself.

These responses were broadly directed against multiple Gag epitopes, both previously reported and some novel epitopes.

Whereas, vigorous proliferative responses directed at the Gag proteins were detected in several individuals, Env-specific proliferation was observed in only one subject.