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Pharmacological data should directly be fit to specific models and parameters derived from that direct fit.
To overcome this problem, a direct fit algorithm is suggested to calculate the coefficients of the frequency components.
We obtained the electrostatic charges of HT-T and HT-AT, calculated at their equilibrium MP2/6-311G+ geometry, by a direct fit of the molecular electrostatic potential.
The OLS GV is a direct fit to concentration and Tk-GV is an inverse solution, virtual concentration fit, and which methods have errors in opposite directions when applied to only 90 min of data.
The RMS norm parameter therefore represents the goodness-of-fit of the estimated input function to the blood-sampled data relative to the goodness-of-fit of a direct fit of Equation 4 to the blood-sampled data.
This is addressed in part by the continuity correction described above and in part by fitting cumulative beta binomials to the respective cumulative observed distributions by minimizing the Kolmogorov-Smirnov statistic [21] rather than carrying out a direct fit for the corresponding density functions.
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Stoichiometric Ca2+ dissociation constants were determined by direct fits to the experimental data as described in ref (31).
Therefore, we propose to use direct fits of the nonlinearized form of eq 5, with kLD as the lateral diffusion correction factor.
DOI: http://dx.doi.org/10.7554/eLife.08825.008 The subjects were able to adapt their decision-making to these different hazard rates, as assessed by direct fits of their choice data by the normative model.
(B ) Subjective hazard rate, estimated from direct fits of choice data by the normative model with hazard rate as a free parameter, plotted as a function of objective hazard rate.
(E – G ) Difference in the best-fitting leak to the two coherences predicted by each of the models above plotted against the difference in leaks from the direct fits to the choice data, separated by hazard rate (see panel B ). Differences are normalized by sum of leaks from each of the coherences.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com