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In order to address these types of inquiry, direct experimentation is needed, and MOA hypotheses should be empirically challenged using experimental studies, in accordance with the scientific method.
Mr. Specter said he believed that at least 75 senators supported federal financing for research, though he did not say whether that included support for his proposal to lift the ban on direct experimentation on live embryos.
Simulations were conducted and compared with direct experimentation.
Direct experimentation on the individual patient is also possible in very limited circumstances.
(1) Direct experimentation is needed to assess habitat function for motile species such as fish.
Testing can involve direct experimentation or the generation of predictions about as-yet-unobserved facts that can be evaluated by further observation.
Similar(24)
Retrospective analysis of splicing in cells with naturally-occurring mutations has been informative but is not compatible with directed experimentation and lacks appropriate isogenic controls [15], [16], [17].
Statistical associations between motif matches in promoters and expression patterns or functional categories of genes also provide a ready starting point for directed experimentation, for example, analysis of gene expression in mutants.
This is an additional experimental condition we are planning to exploit in future along with direct animal experimentation to validate our findings.
My colleague Richard Lenski, whose own long-term investigation of evolving populations of E. coli set a new standard for direct evolutionary experimentation, likes to point out that such observations of evolution in action are not really new but have been taking place since Darwin's own time.
The mechanisms by which these patterns arose will have to be determined separately, most likely by direct biochemical experimentation.
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