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Such NAHR may produce two reciprocal products; a tandem (or direct) duplication and a deletion.
In addition, it has been proposed that the tRNA molecule originated by direct duplication of an RNA hairpin structure [3], [4], [21].
A direct duplication was demonstrated by dual-color FISH with BAC RP11-53M11 and CEP8.
Unequal crossover between those 8 bp resulted in a tandem direct duplication of this 1,269 bp sequence.
Reversed Ac ends transposition (RET) during DNA replication generates Tandem Direct Duplication (TDD) and Composite Insertion (CI).
Some of the genes in each of the clusters were transcribed from the same strand, indicating that they might have arisen by direct duplication [Figure 3].
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DNA transposons generate, upon insertion, direct duplications of short genome sequences (TSDs).
Two large clusters of direct duplications are found (at around the coordinate 36.5-Mb and 36.65-Mb 36.65-Mbe of the duplicandone is 18-kb in size.
DOI: http://dx.doi.org/10.7554/eLife.03724.003 10.7554/eLiFigure24.004 Figure 1 figure supplement 1. Reversed Ac ends transposition after DNA replication generates Tandem Direct Duplications (TDDs).
Our recent work showed that the P1-ovov454 allele undergoes RET to generate derivative alleles containing either deletions or Tandem Direct Duplications (TDDs; Figure 1 figure supplement 1).
The 5' TIR started with the sequence CCCGT- and TIR alignment revealed one mismatch, and lack of internal direct duplications or palindromes (not shown).
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