Sentence examples for direct dosing from inspiring English sources

To circumvent the blood-brain barrier, which prevents most molecules from leaving the bloodstream and entering the brain, Alnylam has looked to a different delivery mechanism: direct dosing of unpackaged siRNAs.

Sporadic low-level copy numbers suggested gene transfer of anywhere from 0.002 copies per cell up to 0.5 copies per cell was possible; however, DNA PCR was positive in lungs prior to direct dosing suggesting aspiration from the nasal dosing.

This study included direct dosing of the neonates, and was designed specifically to investigate renal development and to ensure that the bioactive peptides were not associated with the same type of fetopathy exhibited by ACE inhibiting drugs.

Since an optimal study design for testing potential developmental neurotoxicants in rats, should include exposure during both the pre- and postnatal periods of brain development, we suggest that in the case of triclosan, direct dosing of pups may be the best way to obtain that goal.

In short, there is disagreement about whether direct dosing of pups precludes the need to control for litter effects (e.g., Eriksson 2008; Hardy and Stedeford 2008).

Further considerations of methodologic issues related to the conduct of the DNT study include an ILSI workshop on the direct dosing of preweaning mammals.

Laboratory investigations subsequently documented a direct dose-dependent enhancement of 5-FU cytotoxicity with increasing concentrations of levamisole against human cancer cell lines.

Such corrections are also essential if the full potential of direct dose rate measurement in reducing the overall uncertainty in a luminescence age to much below 5% is ever to be realised.

Varying LN while maintaining a constant MC formulation (G∗ = 565 Pa) revealed a threshold response for neuronal viability, whereas a direct dose-dependent response to LN density was observed for neurite outgrowth.

These findings suggest that AVP causes direct, dose-dependent vasodilation in the human forearm that may be mediated by V2 vasopressinergic receptors.

For the most strains tested, there was no direct dose-dependent effect of the biosurfactant on the adhesion of resting cells.