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"For anybody that wants to follow in our footsteps, this is a direct disruption of freedom of speech, this is like a muzzle," Fara said, adding that they will keep fighting the ruling.
Directly ionizing radiation (e.g., a beam of protons, alpha particles, or beta particles) causes direct disruption of the atomic or molecular structure of the tissue through which it passes.
Recently, Lu et al. [26] have proposed that the influence of AuNPs on CYP2B1-mediated stereoselective metabolism may be due to a combined effect of direct disruption of enzyme conformation and indirect alteration in ionic strength of microenvironment for co-factor production.
This indicates that artemisinin and its related derivative OZ209 kill malaria by a similar mechanism all through direct disruption of mitochondrial functions.
Rituximab cytotoxicity is mediated by different mechanisms; ADCC, CDC, direct disruption of signalling pathways and the triggering of apoptosis.
Numerous studies have demonstrated that direct disruption of the mitochondrial electron transport chain (ETC) can produce large effects on lifespan.
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A direct disruption or punctation of the vertebral artery, however, will not be avoided by IOUS.
Thus, the therapeutic hypothesis was that passive immunization with bapineuzumab would remove Aβ plaques from the brains of AD patients, most probably via stimulation of microglial activation, but also potentially via direct mechanical disruption of Aβ plaque mediated by antibody binding 99 and the direct inhibition of Aβ fibrillogenesis.
Our results demonstrate a clear role for CTCF in rDNA regulation, but formally we cannot show that this effect is direct, since disruption of CTCF or PARP/PARG are expected to have pleiotropic effects on other genes in the genome.
While it is recognized that flooding is a natural process that can rejuvenate and benefit many rivers and floodplain areas, flooding can also lead to the direct displacement and disruption of aquatic life.
The direct action produces disruption of sensitive molecules in the cells, whereas the indirect effects (∼70%) result from its interaction with water molecules, which results in the production of highly reactive free radicals such as ·OH, ·H, and eaq− and their subsequent action on subcellular structures.
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