Sentence examples for direct blockade from inspiring English sources

The direct blockade of this step has long been recognized as most attractive for therapeutic intervention.

Coregulator recruitment is a crucial regulatory step in AR signaling and the direct blockade of coactivator binding to AR offers the opportunity to develop therapeutic agents that would remain effective in prostate cancer cells resistant to conventional endocrine therapies.

For example, the direct blockade of RhoA with an inhibitor may disrupt other, crucial Rho-related cellulactivitiesies.

At our knowledge, only two reports evaluate the hypothesis by direct blockade of the transcriptional machinery [23], [24].

Such disinhibition might be due to a direct blockade of NMDAr in interneurons and/or to a blockade of presynaptic, NMDA-dependent release of glutamate [46], [47].

This is triggered by the direct blockade of NMDA receptors.

Notably, direct spinal blockade of MGL has similar beneficial effects, which also require spinal CB1 receptors (Suplita et al., 2006).

The authors hypothesised that the rise in plasma ET-1 reported with atrasentan was the result of direct ETA blockade (Carducci et al, 2002).

These results regarding migration versus degranulation are consistent with the observation that HLMC migration is also far more sensitive to direct KCa3.1 blockade than degranulation 14, 17.

Such an effect would provide a second molecular 'brake' on heparanase 1 activity in addition to the already established direct biochemical blockade on this protein conferred by heparanase 2 (17).

Hence, it was felt that direct NCX blockade with small molecule inhibitors may yield results that could be more difficult to interpret than modulating NCX function via alterations in [Na+]o to counteract the changes in [Na+]o:[Na+]i gradient caused by INa blockade.