Sentence examples for direct and functional from inspiring English sources

Next, we identified direct and functional target genes of MafB by intersecting genes regulated by MafB in retinal ECs with MafB-bound genes identified in the ChIP-Seq analysis.

http://thebiogrid.org/ STRING Database of known and predicted protein interactions, including both direct and functional associations.

Furthermore, phospholipase D1 (PLD1), a putative cell apoptosis suppressor in GC, is characterized as a direct and functional target of miR-638, which provides a possible regulation pathway for PLD1 and a candidate target forthediagnostics and treatment of GC.

In the functional network, PPI contains both physical (direct) and functional (indirect) interactions.

The yeast protein-protein interaction (PPI) network used here was retrieved from STRING [28] (http://string.embl.de/), whose primary mission is to provide researchers with both physical (direct) and functional (indirect) interactions.

The enrichment of cognate seed matches in computationally predicted favorable contexts and the correlation between specific miRNA-dependent Ago2-IP enrichment and changes in mRNA levels are strong evidence that the assay reflects a direct and functional interaction between the transfected miRNA and the Ago2 IP-enriched mRNAs.

We identify a direct physical and functional interaction between METTL3 and the eukaryotic translation initiation factor 3 subunit h (eIF3h).

To establish direct causal and functional associations between genotype and phenotype, it is hence indispensable to observe intermediate molecular levels, such as transcript, protein and metabolite abundance.

Here, we explored the direct structural and functional effects of fetal and adult cardiac fibroblasts on cardiomyocytes using a tissue-engineered 3D co-culture system.

Recent developments in targetable epigenome-editing tools enable us to assign direct transcriptional and functional consequences to locus-specific chromatin modifications.

The concept of osseointegration has thus significantly broadened from its original sense to its definition as a direct structural and functional connection between living alveolar bone and the dental implant as a load-carrier.