We observed an apparent diminution of response at week 16 (prior to the third dose of study agent), but also noted a peak effect at weeks 24 28.
Notwithstanding the variability, we did not observe any consistent changes over time (i.e. diminution of the response) that would suggest habituation was occurring.
Using the CR model, we then attempted to verify the published result that orexin deletion diminishes food anticipatory activity (FAA) but observed little to no diminution in the response to CR and, surprisingly, that orexin KO mice are refractory to body weight loss on a CR diet.
Effective concentrations of carbon disulfide produced both a rise in the amount of electric shock tolerated and a diminution of the response force exerted by the monkeys.
Habituation is a sign of non-associative learning in which there is a progressive diminution of behavioral response probability with repetition of a stimulus or to an environment, which is thus partly altered in Ts1Yah mice.
The primary outcomes considered were the radiological response (diminution or stabilization of tumor volume assessed through serial CT or MRI) and the clinical improvement, either subjectively declared from the patients or objectively assessed through a medical examination, evaluated during and/or after treatment administration.
This impairment is associated with progressive diminution of mitogen responses by spleen cells harvested from tumor free VP-16 treated mice.
In this study, the FICP was able to deted a dose-response diminution of protein expression where immunoblotting failed to do it probably because of the limitation on the amount of total proteins that can be loaded on the eledrophoretic gel or the loss of cydin D1 protein during the cell washes in the Western blot procedure, due in part to cytotoxicity-induced membrane permeability.
Hence, gradual diminution in the eCBmGluR response depended on the presence of both the DAGL inhibitor and repeated DHPG stimulation, and could not be explained simply by the duration of the inhibitor application.
Diminution of the somatic response, the PS, reflects a reduction in excitability of the cell.
A restructuring and diminution of his responsibilities was being discussed before he resigned last year.
