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Cancer chemotherapy often depletes the stem and progenitor cells involved in platelet proliferation, which leads to a diminution of platelets and temporary interruption of platelet production lasting until stromal elements and megakaryocytes regenerate.
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The correlation between increased platelet count and hypercortisolism is extremely controversial, as most of the studies aimed to demonstrate this correlation have evaluated patients with immune-mediated disorders (e.g., immune-mediated thrombocytopenia), and consequently, an increase of platelet number would be expected after corticotherapy due to a diminution of platelet destruction [ 10].
& Rowsell, H.C. Role of platelets in thrombosis.
Immunophenotypic analysis of platelets.
Flow cytometric analysis of platelets.
Tiny granules within platelets contain substances important for the clot-promoting activity of platelets.
The yield of platelets drawn during an apheresis procedure is equal to the amount of platelets collected from five donations of whole blood.
The biogenesis of platelets from megakaryocyte proplatelets.
Megakaryocytes and beyond: the birth of platelets.
We sense a diminution of our cosmos.
There is a diminution of complexity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com