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Reduction of the peptide size below 30 amino acids resulted in a significant diminution of activity.
They are places like the South Loop in Chicago or downtown Brooklyn in New York -- where the mix of residents and workers means that day turns seamlessly into night with little diminution of activity.
A/D transition can be considered a natural intrinsic mechanism providing diminution of activity of the respiratory chain during the initial phase of reoxygenation and would protect mitochondria from irreversible damage.
The oncogenic shock hypothesis relies on the experimental observation that targeted disruption of signal-generating oncoproteins results in differential kinetics of downstream signal decay: anti-apoptotic effectors (such as ERKs, AKT and STATs) display rapid diminution of activity; conversely, death-inducing molecules (namely p38) display delayed accumulation.
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Because a decrease of oxygen concentration below the physiological threshold (1 5%) induces a metabolic shift from oxidative phosphorylation towards anaerobic glycolysis with the consequent diminution of mitochondria activity (revised in [25]), we assessed the mitochondrial activity of IhNSC cultured at different oxygen conditions and correlated it with the apoptotic score.
However, previous clinical studies showed an insufficient antitumor activity of MEK inhibitors [ 39], suggesting that the MEK/ERK phosphorylation pathway is resilient to diminution of the activity of MEK and can adapt rapidly to maintain nearly normal ERK activation [ 39].
Since insulin is an activator of LPL, it has been suggested that the diminution of LPL activity may be due to a relative insulin deficiency and/or insulin resistance.
No one contests that when the planet palpably cooled from 1645 to 1715 — the Maunder minimum, which saw the freezing of the Thames — there was a diminution of solar activity.
We find a diminution of ADAMTS13 activity (before PE) with an average of 53% [40 70] in this group.
This phenomenon was not initially observed in potato cyst nematode G. pallida J2s, which displayed no aberrant phenotype, or diminution of migratory activity in response to the same 0.1 mg/ml dsRNA 24 h soaks.
These results demonstrate that ozonolysis is an important tool for the removal of unsaturated uronate residues from LMWHs and heparosan without modification of the core polysaccharide structure or diminution of anticoagulant activity.
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CEO of Professional Science Editing for Scientists @ prosciediting.com