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MIC (minimum inhibitory concentration) values were determined visually as the lowest concentration of drug that caused significant growth diminution levels (≥ 50%).
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However, it was also demonstrated that the low phytate seeds had an undesirable diminution in levels of myo-inositol and ascorbate, which probably led to sensitiveness of seeds to abscisic acid during germination.
The resulting reduction in total muscle mass, together with a decrease in the abundance of contractile proteins, as well as the diminution in levels of ATP and creatine phosphate (PCr) provide an explanation for the impaired muscle function.
There is now little dispute that aging process is associated with the combined diminutions (retarded levels or loss of effectiveness) of important hormones and metabolites, enzymes and/or receptor molecules and immune responses in organs/tissues.
Overexpression of atwhy2 in plants perturbs mitochondrial function by causing a diminution in transcript levels and mtDNA content which translates into a low activity level of respiratory chain complexes containing mtDNA-encoded subunits.
Therefore the diminution of SAH levels could be due to other genes located on chromosome 21.
When the same experiment was repeated using RoboSD instead of Robo, no significant diminution in protein levels was observed.
The 24 h time point was chosen to better show that parthenolide at higher concentrations causes a sustained diminution in mRNA levels.
For ELA1 gene both shRNA clones show lower diminution in mRNA levels (figure S4E), but the replication assays indicate a high reduction in HIV-1 replication.
Some diminution in FoxP3 levels might be expected because acute activation increases FoxP3 protein expression [2], and such activation would not occur in the mutant Treg cells.
Marx et al. have also recently observed diminution of ErbB2 levels in breast cancer cell lines following application of the proteasome inhibitor Velcade/Bortezomib [30].
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