Sentence examples for diminution in the expression of from inspiring English sources

In that report, Chen et al. demonstrated that a diminution in the expression of cell surface MICL inhibited or augmented cytokine production in a stimulus-dependent manner.

Furthermore, Rituximab therapy is associated with a down-regulation of CD40L in T cells as well as a diminution in the expression of activation markers in these lymphocytes [ 32].

A diminution in the expression of MICL induced by antibody cross-linking or siRNA enhanced the MSU-dependent increase in cytoplasmic calcium levels, protein tyrosine phosphorylation and IL-8 but not IL-1 production.

Embryos injected with control MO exhibited normal forebrain development, whereas fezf2 MO caused significant disruption in the development of the forebrain, as revealed by diminution in the expression of the rostral forebrain-specific marker arx (Fig. 1A) as well as the anterior neural markers otx2 and pax6 at stage 30 (supplementary material Fig. S4A) (El-Hodiri et al., 2003).

This analysis showed that although there was a significant diminution in the expression levels of ΔNp63 transcripts with differentiation, surprisingly under no conditions was TAp63 expression detected (Additional file 5: Figure S3)—a finding that corroborates well with the results of RNA polymerase II ChIP experiments on the p63 TA and ΔN promoters [ 45].

In general, inhibition of HDAC activity will lead to increased histone acetylation, which in turn will mostly result in gene activation, thus the diminution of the expression of inflammatory and fibrotic genes in an experimental setting is most likely due to indirect targeting through miRNAs or other transcriptional repressors.

These mice overexpress the expected enzymes, with increases of two- to four-fold in all tissues tested and no diminution of the expression of other major antioxidant enzymes (Raineri et al., 2001; Chen et al., 2003; Mele et al., 2006).

We provide evidence that the 50C1-induced diminution of the expression of cell surface MICL significantly enhanced the MSU-induced increase in cytoplasmic free calcium.

The graded and significant diminutions in the serum concentrations of testosterone in response to graded doses of calcium chloride were correlated with graded diminutions in the expressions and activities of testicular 3β- HSD and 17β- HSD, especially as these are key enzymes for testicular androgenesis [ 19].

Thus, we next explored the possibility that Nrf2 could be playing a pivotal role in the observed diminished total plasma LOOH levels in mice that fed a HFHC diet treated with RG with respect to either LST treated and untreated hypercholesterolemic mice as well as in the observed diminution in the relative expression levels of CD36 gene in the RG mice group with respect to the mice LST group.

Results obtained by immunoblot analysis showed a diminution in expression of cyclin D1 protein in cells treated with cydopentenone when compared to untreated control cells (Fig. 2B).