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With the synthetic group I mGlu agonist DHPG, once again, the majority of mutant mGlu1 receptors display a loss of function relative to mGlu1 WT (typically 55 75% of WT response); however, K563N displays a slight gain of function (∼110% of WT), and P1015A only exhibits a slight diminution in activity (∼90% of WT response), suggesting some role for ligand bias across the mutants.
Similar(59)
"And so over the next 18 months you will see a sharp diminution in research activity.
Of late, though, Ms. Schifter has noted a slight diminution in paper activity.
Any diminution in his activity at the Met will be hard to offset at a comparable level.
A recent spate of articles has laid the blame for the diminution in heterosexual activity on another, less obvious, source: feminism.
The production of both male and female hormones also diminishes with age, though this cannot be directly related to the gradual diminution in sexual activity that occurs in both males and females between 20 and 60.
Similarly, experimental studies have shown a diminution in antioxidant activity in patients with osteoporosis [ 9, 10].
By contrast, a diminution in AO activity improved tomato yield under water deficit [ 54].
While the values of all the analyzed parameters for both BM and MVM from explants cultured in normoxic conditions are quite similar to those shown in Table 2 (freshly prepared explants), the membranes prepared from explants cultured under hypoxic conditions showed an increase in lipid peroxidation and Ca2+ content, as well as an important diminution in PMCA activity.
As shown in Figure 5C, siRNA-transfected MCF-7 cells exhibited a marked diminution in the activation of ATM, ATR, Chk1, and Chk2 kinases after IR exposure (ATM activity, Chk2 activity, ATR activity and Chk1 activity).
Alternatively, reduction in pH resulted in marked diminution in factor VIIa activity from both tissue factor dependent and independent mechanisms.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com