The relationship between age-associated thymic involution and diminution of ovarian function is evidenced by the alteration of ovarian function in neonatally thymectomized mice [ 129].
Thus, cardiac ilk KD with hand- Gal4 is likely to cause more severe diminution of ilk function than the expected 50% reduction in function of ilk heterozygous mutants or with GMH5-mediated KD (see Fig. S3).
"Even in those having partial nephrectomies, there's a continued diminution in kidney function," said Dr. Paul Russo, the senior author of the paper, "but much less than in those who have the radical operation".
Diminution in synaptic function and loss of normal synaptic architecture are likely to be the biologically relevant substrate for neurologic deficits in patients with HIV-1-associated dementia (HAD) and patients suffering from the prionoses.
Pharmacologic intervention for symptoms of pain may cause sedation and associated diminution of neurocognitive function.
16 Diminution of immune function with age is associated with a decline in the production of growth hormone, estrogen, dehydroepiandrosterone, and melatonin.
In the aging intervertebral disc, there is a well-recognized loss of cells, which puts the remaining cell population at risk for any diminution in cell function.
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disorder resulting from unrelenting matrix deposition and diminution of lung function (Bjoraker et al., 1998; Eickelberg and Selman, 2010).
Other study showed beta-cell function diminution which was progressive according to the number of Leu copies [ 10], and another demonstrated heterozygotes to have higher insulin sensitivity than both Ile and Leu homozygotes, albeit in an ethnically heterogeneous sample [ 9].
TFs are significantly shorter, and have a reduced disorder in hyperthermophiles in a way reminiscent of the situation in prokaryotes as a group in comparison to eukaryotes [46], [47], where shorter and less disordered TFs mark the diminution in regulatory functions, i.e. functional complexity.
